Who Abuses Zanaflex And Why?

People who receive a prescription for medicine tizanidine are at risk of abusing this drug and developing a strong addiction.

An NCBI case study reports a case of a 31- year old woman who started to take too many tizanidine pills after starting her muscle contracture therapy.

This patient was advised to take 2 mg every 24 hours. Shortly after commencing her therapy, this woman increased her tizanidine capsule intake to 2 mg per 3 hours! This means that the patient presented here ingested more than ten tizanidine tablets daily.

Various symptoms appeared soon after this patient began to increase her Zanaflex dose. This patient likely wanted to quickly resolve the muscular issues for which she received a drug prescription in the first place.

What is Zanaflex high? It’s important to note that there is no such thing as tizanidine high euphoria, and people who acquire Zanaflex addiction usually want to reverse the symptoms of their medical condition.
Nevertheless, some people indulge in concurrent abuse with other psychoactive substances and medicines.

This type of use can cause a plethora of health complications. To preclude this, always consult a doctor.

Brand And Street Names of Zanaflex

What are other brand names for tizanidine hydrochloride?

Besides Zanaflex medication, there are other brand names such as:

      • Arzan
      • Sirdalud
      • Tidired
      • Tizonec
      • Tizpa

The substance is also available in the generic medication form. There are also many street and slang names for tizanidine pills, as it is abused by a handful of drug addicts who buy and sell it illegally on streets. Zanaflex street value is rather high when compared with the usual price one would pay in a pharmacy store.

Is Tizanidine Addictive ?

Like many prescription medications, tizanidine can be addictive. Some people deliberately misuse the medication, while others may develop an addiction over time.

Tizanidine is an FDA-approved medicine for the management of spasticity caused by:

    • An acquired brain injury
    • Multiple sclerosis
    • Spinal cord injury

It is also used in the management of pain associated with:

    • Lumbosacral neuralgia and chronic neck issues
    • Musculoskeletal pain syndrome
    • Migraine headaches

Tizanidine medication is an off-label prescription used as an anticonvulsant for the management of migraine headaches and insomnia.

Tizanidine abuse is possible due to its fast action on pain. A study to compare the muscle strength of Tizanidine and other approved skeletal muscle relaxants showed that there was increased improvement with Tizanidine.

What Is Tizanidine?

It is an antispasmodic prescription drug that is taken orally at specified intervals of time to treat symptoms related to multiple sclerosis, stroke, spinal and brain injury. In simple terms, Tizanidine is a sharp pain-relief medicine that is acquired only with a doctor’s prescription.

Is Tizanidine a narcotic? No. Just because Tizanidine is sometimes abused doesn’t qualify it as a narcotic. Narcotics are substances traditionally used to ease pain by binding to pain receptors in the nervous system, whereas Tizanidine is a muscle relaxer. While Tizanidine muscle relaxers may help reduce pain, they do so in a different way than narcotics. Tizanidine is a muscle relaxer and blocks pain around the skeletal muscle areas. It is an alpha-2 adrenergic agonist that treats:

    • Cramping
    • Spasm
    • Tightness of muscles

Symptoms that may warrant Tizanidine use may be the result of:

    • Injury to the spine or central nervous system
    • Spastic diplegia
    • Back pain
    • Multiple sclerosis

What Is Tizanidine Used For?

Spasm and muscle tone are common in people who have experienced a stroke, multiple sclerosis, brain or spinal injury. Since the body functions abnormally during contraction and muscle tone, Tizanidine is used to slow down the brain and nervous system action so that the muscles can relax.

You might have seen people taking Tizanidine for other medical conditions and wondered what is Tizanidine used for? Tizanidine can be used to treat several medical conditions, including:

    • Spinal cord or acquired brain injuries
    • Multiple sclerosis
    • Regional musculoskeletal pain syndrome
    • Chronic neck and lumbosacral neuralgia

Other uses for Tizanidine include treatment for:

    • Insomnia
    • Migraine headaches
    • Anticonvulsant

Tizanidine can also be used as part of a detoxification regimen in rebound headaches caused by analgesic withdrawal.

Is Tizanidine Addictive?

Though Tizanidine isn’t a narcotic, it can be addictive. You can’t get self-prescribe or over-the-counter Tizanidine due to its addictive nature. Instead, it is available with a doctor’s prescription. All medical instructions should be followed closely. Most medicines that act on the central nervous system (brain) have withdrawal effects when stopped immediately.

When a person is under this type of medication, the doctor will gradually reduce the dose to avoid withdrawal symptoms. The withdrawal symptoms may include:

  • Hypertension
  • Tachycardia
  • Tremor
  • Anxiety
  • Hypertonia

Tizanidine withdrawal can be managed by restarting and gradually reducing the dosage until the cessation of the medication.

You might be wondering how Tizanidine is addictive. When Tizanidine is taken more than 35 mg within 24 hours for more than two weeks, you risk the chance of being addicted to it. High doses of Tizanidine range from 20 mg to 36 mg daily.

If you are taking Tizanidine in high doses for more than nine weeks, it is advisable not to stop without professional help due to:

  • Rebound hypertension
  • Increased spasticity
  • Tachycardia

Tizanidine recreational use is rising by the day, and most people combine it with other narcotics to achieve the feeling of a Tizanidine high. The high feeling usually lasts for a shorter time, and this may lead to a person taking more doses to stay high.

Tizanidine Street Names, Common Misspellings, and Generics

Although Tizanidine is a prescription medication, it may be sold illegally and be known by a variety of street names. Although Tizanidine is a generic medication itself, it may be known by other brand names.

Tizanidine brand names include:

  • Zanaflex
  • Sirdalud(Novartis)
  • Relentus(Beximco Pharma)

Tizanidine is sometimes misspelled deliberately or unknowingly. Sometimes people misspell it to hide the fact they are using the medicine incorrectly or illicitly. Common misspellings or variants include:

  • Tizanadine
  • Xanaflex

Tizanidine Ingredients

Tizanidine is made up of active and inactive ingredients to form a muscle relaxer that is effective for many patients. The ingredients found in Tizanidine can cause liver damage, especially if you have liver problems.

Active ingredient:

  • Tizanidine hydrochloride(HCL)

Inactive ingredients:

  • Gelatin
  • Colorant
  • silicon dioxide
  • Hypromellose
  • Sugar spheres
  • Titanium dioxide

Tizanidine Warnings

Tizanidine side effects are present after the medication is abruptly stopping. Most Tizanidine warnings are related to withdrawal of the medicine. Related warnings include:

  • Hypotension
  • Liver injury
  • Sedation. You can’t drive while taking Tizanidine medication
  • Hallucination
  • Hypersensitivity reactions
  • Withdrawal adverse reactions
  • Nonclinical toxicology( carcinogenesis, mutagenesis, fertility impairment).

Since it isn’t clear how the medicine affects a pregnant person, it is advisable to avoid Tizanidine unless it is used to save a life. Since it isn’t clear whether Tizanidine excretion is through milk, it is advisable to avoid it during lactation.

Symptoms of Overdose of Zanaflex

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

      • drowsiness
      • extreme tiredness
      • confusion
      • slow heartbeat
      • fainting
      • dizziness
      • slow or shallow breathing
      • loss of consciousness

What other Drugs could Interact with Zanaflex?

There may be an interaction between tizanidine and any of the following:

      • abiraterone
      • acetaminophen
      • acyclovir
      • alcohol
      • aldesleukin
      • aliskiren
      • alpha agonists (e.g., clonidine, methyldopa)
      • alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin)
      • amifostine
      • angiotensin converting enzyme (ACE) inhibitors (e.g., captopril, lisinopril, ramipril)
      • antiarrhythmics (e.g., amiodarone, disopyramide, dofetilide, dronedarone, flecainide, mexiletine, procainamide, quinidine)
      • anti-psychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
      • antihistamines (e.g,. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
      • barbiturates (e.g., butalbital, pentobarbital phenobarbital)
      • benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
      • beta-blockers (e.g., carvedilol, propranolol, timolol)
      • birth control pills
      • brimonidine
      • buprenorphine
      • buspirone
      • caffeine
      • calcium channel blockers (e.g., amlodipine, diltiazem, verapamil, nifedipine)
      • cannabis
      • chloral hydrate
      • chloroquine
      • cimetidine
      • deferasirox
      • degarelix
      • digoxin
      • diuretics (water pills; e.g., furosemide, hydrochlorothiazide, spironolactone)
      • domperidone
      • donepezil
      • efavirenz
      • estrogens (ethinyl estradiol, conjugated estrogen)
      • famotidine
      • fingolimod
      • galantamine
      • gemfibrozil
      • general anesthetics (medications used to put people to sleep before surgery)
      • guanfacine
      • hydralazine
      • ivabradine
      • kava kava
      • ketoconazole
      • lanreotide
      • lidocaine
      • macrolide antibiotics (e.g., clarithromycin, erythromycin)
      • magnesium sulfate
      • methadone
      • methoxsalen
      • mifepristone
      • mirtazapine
      • muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)
      • nabilone
      • narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
      • nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
      • obinutuzumab
      • octreotide
      • olopatadine
      • pasireotide
      • phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
      • pramipexole
      • primaquine
      • protein kinase inhibitors (e.g., ceritinib, lapatinib, pazopanib, sunitinib, vemurafenib)
      • quinine
      • “quinolone” antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
      • rilpivirine
      • rivastigmine
      • ropinirole
      • rotigotine
      • saquinavir
      • scopolamine
      • seizure medications (e.g., clobazam,levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
      • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
      • serotonin antagonists (anti-emetic medications; e.g., dolasetron, granisetron, ondansetron)
      • serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
      • tapentadol
      • tetrabenazine
      • thalidomide
      • ticlopidine
      • tramadol
      • tranylcypromine
      • trazodone
      • tricyclic antidepressants (e.g., amitriptyline, desipramine)
      • voriconazole
      • zolpidem
      • zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

      • stop taking one of the medications,
      • change one of the medications to another,
      • change how you are taking one or both of the medications, or
      • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Precautions of Zanaflex

It is important that your doctor check your progress at regular visits, especially during the first few weeks of treatment with this medicine. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects.

White Round U 169 - Tizanidine Hydrochloride 4mg Tablet

Do not use this medicine together with ciprofloxacin or fluvoxamine. Using these medicines together may cause serious unwanted effects.

Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

White Round M 724 - Tizanidine Hydrochloride 4mg Tablet

This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, barbiturates, medicine for seizures, other muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using tizanidine.

White Round Apo Ti-4 - Tizanidine Hydrochloride 4mg Tablet

This medicine may cause dizziness, drowsiness, lightheadedness, clumsiness or unsteadiness, or vision problems in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert, well-coordinated, and able to see well.

Hallucinations (visual) may occur while you are using this medicine. Check with your doctor right away if you have hallucinations (seeing things that are not there).

White Oval R180 - Tizanidine Hydrochloride 4mg Tablet

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

White Round E 44 - Tizanidine Hydrochloride 4mg Tablet

Do not suddenly stop taking this medicine without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms.

White Round 503 - Tizanidine Hydrochloride 4mg Tablet

Tizanidine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if dry mouth continues for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Dosing of Zanaflex


The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (capsules or tablets):
    • For muscle relaxation:
      • Adults—At first, 2 milligrams (mg) every 6 to 8 hours. Your doctor may adjust your dose as needed. Do not take more than 36 mg within a 24-hour period.
      • Children—Use and dose must be determined by your doctor.