There may be an interaction between tizanidine and any of the following:
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- abiraterone
- acetaminophen
- acyclovir
- alcohol
- aldesleukin
- aliskiren
- alpha agonists (e.g., clonidine, methyldopa)
- alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin)
- amifostine
- angiotensin converting enzyme (ACE) inhibitors (e.g., captopril, lisinopril, ramipril)
- antiarrhythmics (e.g., amiodarone, disopyramide, dofetilide, dronedarone, flecainide, mexiletine, procainamide, quinidine)
- anti-psychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- antihistamines (e.g,. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- barbiturates (e.g., butalbital, pentobarbital phenobarbital)
- benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
- beta-blockers (e.g., carvedilol, propranolol, timolol)
- birth control pills
- brimonidine
- buprenorphine
- buspirone
- caffeine
- calcium channel blockers (e.g., amlodipine, diltiazem, verapamil, nifedipine)
- cannabis
- chloral hydrate
- chloroquine
- cimetidine
- deferasirox
- degarelix
- digoxin
- diuretics (water pills; e.g., furosemide, hydrochlorothiazide, spironolactone)
- domperidone
- donepezil
- efavirenz
- estrogens (ethinyl estradiol, conjugated estrogen)
- famotidine
- fingolimod
- galantamine
- gemfibrozil
- general anesthetics (medications used to put people to sleep before surgery)
- guanfacine
- hydralazine
- ivabradine
- kava kava
- ketoconazole
- lanreotide
- lidocaine
- macrolide antibiotics (e.g., clarithromycin, erythromycin)
- magnesium sulfate
- methadone
- methoxsalen
- mifepristone
- mirtazapine
- muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)
- nabilone
- narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
- nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
- obinutuzumab
- octreotide
- olopatadine
- pasireotide
- phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
- pramipexole
- primaquine
- protein kinase inhibitors (e.g., ceritinib, lapatinib, pazopanib, sunitinib, vemurafenib)
- quinine
- “quinolone” antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
- rilpivirine
- rivastigmine
- ropinirole
- rotigotine
- saquinavir
- scopolamine
- seizure medications (e.g., clobazam,levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
- serotonin antagonists (anti-emetic medications; e.g., dolasetron, granisetron, ondansetron)
- serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
- tapentadol
- tetrabenazine
- thalidomide
- ticlopidine
- tramadol
- tranylcypromine
- trazodone
- tricyclic antidepressants (e.g., amitriptyline, desipramine)
- voriconazole
- zolpidem
- zopiclone
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If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
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- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
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An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.